{"id":11,"date":"2020-10-03T14:51:12","date_gmt":"2020-10-03T18:51:12","guid":{"rendered":"http:\/\/demo.athemes.com\/sp-plumber\/?page_id=11"},"modified":"2022-11-06T00:29:35","modified_gmt":"2022-11-06T04:29:35","slug":"services","status":"publish","type":"page","link":"https:\/\/novabiologiques.com\/?page_id=11","title":{"rendered":"Discovery and Development"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"11\" class=\"elementor elementor-11\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bf7f744 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bf7f744\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4db1355\" data-id=\"4db1355\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4866997 elementor-widget elementor-widget-heading\" data-id=\"4866997\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Discovery and Development<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a99293 elementor-widget elementor-widget-text-editor\" data-id=\"9a99293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/novabiologiques.com\/\">Home<\/a><\/span>\u00a0 \u00a0 |\u00a0 \u00a0 <span style=\"text-decoration: underline;\">Discovery and Development<br \/><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-12b76ba elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12b76ba\" data-element_type=\"section\" data-e-type=\"section\" id=\"hum\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-40e8520\" data-id=\"40e8520\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4a4ce32 elementor-widget elementor-widget-image\" data-id=\"4a4ce32\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"human\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/novabiologiques.com\/wp-content\/uploads\/2022\/11\/test_bp_3.238.pdb_.png\" class=\"attachment-medium size-medium wp-image-801\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a66ec6 elementor-widget elementor-widget-image\" data-id=\"8a66ec6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/novabiologiques.com\/wp-content\/uploads\/2022\/11\/6vxx.pdb03.png\" class=\"attachment-sydney-medium-thumb size-sydney-medium-thumb wp-image-827\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9179058\" data-id=\"9179058\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f5081ab elementor-widget elementor-widget-icon-box\" data-id=\"f5081ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tHuman Vaccines\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tTD&trade; Trimer-Domain Technology Platform\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae0bf3b elementor-widget elementor-widget-text-editor\" data-id=\"ae0bf3b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>TD\u2122 Trimer-Domain is a proprietary protein domain that both stabilizes the trimeric structure of the protein and also allows its purification in one easy step.<\/p><p>Key features of TD\u2122 Trimer-Domain:<\/p><ul><li>Development of protein-based vaccines according to the natural trimerized structure.<\/li><li>High-expression in standard CHO cells based bioprocesses.<\/li><li>Rapid one-step purification process.<\/li><li>Currently in an Investigator-Initiated Trial (IIT).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-00bb95e elementor-widget elementor-widget-text-editor\" data-id=\"00bb95e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our human vaccine candidate, SARS-CoV-2 PF-D-Trimer\u2122, consists of the TD\u2122 Trimer-Domain stabilized recombinant viral S-glycoprotein in its prefusion trimeric form. Major proteins of many viruses responsible for human and veterinary diseases, including the S protein of coronaviruses, only exist in a trimeric form.<\/p><p>We are also developing a trimeric vaccine based on the hemagglutinin of the influenza virus. This vaccine candidate also uses the TD\u2122 Trimer-Domain technology.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cb146d1 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cb146d1\" data-element_type=\"section\" data-e-type=\"section\" id=\"vet\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-401dba3\" data-id=\"401dba3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f4d5ee0 elementor-widget elementor-widget-icon-box\" data-id=\"f4d5ee0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tVeterinary Vaccines\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tVirus-Like Particles and Subunit Vaccines\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6de4bbb elementor-widget elementor-widget-text-editor\" data-id=\"6de4bbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Veterinary vaccines have played and continue to play a major role in protecting animal and public health and enable efficient production of food for the burgeoning human population. Animal vaccines can be developed and licensed much more quickly than human vaccines.\u00a0<\/p><p>In order to meet the urgent needs for new veterinary vaccines, Nova Biologiques has developed high-efficiency, low-cost VLP and subunit therapeutic solutions.<\/p><p>One of these vaccines, currently in preclinical studies, protects against Classical swine fever (CSF), one of the most devastating viral infectious diseases affecting members of the Suidae family, which has serious repercussions on the world economy.<\/p><p>We have also developed VLP vaccines for protection against avian influenza and Newcastle disease viruses, two important pathogens in poultry worldwide.<\/p><p>\u00a0<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ed3cea0\" data-id=\"ed3cea0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2962a33 elementor-widget elementor-widget-image\" data-id=\"2962a33\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"veter\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"297\" src=\"https:\/\/novabiologiques.com\/wp-content\/uploads\/2022\/11\/VLP_3dwhite.jpg\" class=\"attachment-medium size-medium wp-image-772\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6f4cc8 elementor-widget elementor-widget-image\" data-id=\"d6f4cc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"550\" height=\"259\" src=\"https:\/\/novabiologiques.com\/wp-content\/uploads\/2022\/11\/2yq3.pdb01.png\" class=\"attachment-sydney-medium-thumb size-sydney-medium-thumb wp-image-928\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6959750 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6959750\" data-element_type=\"section\" data-e-type=\"section\" id=\"hclinic\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-33322ac\" data-id=\"33322ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b559b93 elementor-widget elementor-widget-icon-box\" data-id=\"b559b93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tHuman Clinical Trials\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b2f4a3 elementor-widget elementor-widget-text-editor\" data-id=\"9b2f4a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prophylactic SARS-CoV-2 Vaccine Candidate: PF-D-Trimer\u2122, a broad protective SARS-CoV-2 subunit vaccine developed from our TD\u2122 Trimer Domain platform using the Delta spike protein.<\/p><ul><li>Investigator-Initiated Trial (IIT) in collaboration with our Chinese partners, to evaluate the safety, tolerability, and immunogenicity of PF-D-Trimer\u2122.<\/li><li>The data continues to strengthen the potential of the TD\u2122 platform against coronaviruses and against other viral diseases.<\/li><li>The results from the studies are expected by the end of 2022.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4ae091d\" data-id=\"4ae091d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8b43724 elementor-widget elementor-widget-image\" data-id=\"8b43724\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"hclinict\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"237\" src=\"https:\/\/novabiologiques.com\/wp-content\/uploads\/2022\/11\/iit-gantt.jpg\" class=\"attachment-large size-large wp-image-911\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4cfe499 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4cfe499\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wide\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-266145b\" data-id=\"266145b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-40b0777 elementor-widget elementor-widget-image\" data-id=\"40b0777\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"79\" src=\"https:\/\/novabiologiques.com\/wp-content\/uploads\/2022\/11\/NOVA_BIO_LOGO4-white.png\" class=\"attachment-medium size-medium wp-image-602\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-cb83e7d\" data-id=\"cb83e7d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a8d282f elementor-widget elementor-widget-text-editor\" data-id=\"a8d282f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/novabiologiques.com\/?page_id=3\" data-wplink-url-error=\"true\">Terms of Use<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Discovery and Development Home\u00a0 \u00a0 |\u00a0 \u00a0 Discovery and Development Human Vaccines TD&trade; Trimer-Domain Technology Platform TD\u2122 Trimer-Domain is a proprietary protein domain that both [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page_front-page.php","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/novabiologiques.com\/index.php?rest_route=\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/novabiologiques.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/novabiologiques.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/novabiologiques.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/novabiologiques.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11"}],"version-history":[{"count":170,"href":"https:\/\/novabiologiques.com\/index.php?rest_route=\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":1047,"href":"https:\/\/novabiologiques.com\/index.php?rest_route=\/wp\/v2\/pages\/11\/revisions\/1047"}],"wp:attachment":[{"href":"https:\/\/novabiologiques.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}